Alterations in checkpoint and DNA repair pathways may provide adaptive mechanisms contributing to acquired drug resistance.Here, we investigated the levels of proteins mediating DNA damage signaling and -repair in RPMI8226 multiple myeloma cells and its Melphalan-resistant derivative 8226-LR5.We observed markedly reduced steady-state levels of DNA
Hot-iron branding is illegal in Sri Lanka, but is still commonly used to identify dairy herds in extensive farming systems, which are Faber Hood F-Light Arkea EVO+ INOX Plus Island 60Cm 220-240V 345 0492 562 primarily located in the country’s Dry Zone.Despite the negative welfare implications of this practice, there is no written documentatio
Summary: AAA+ proteins form asymmetric hexameric rings that hydrolyze ICE FREEZE HAIR SPRAY ATP and thread substrate proteins through a central channel via mobile substrate-binding pore loops.Understanding how ATPase and threading activities are regulated and intertwined is key to understanding the AAA+ protein mechanism.We studied the disaggregase